Postdoc - Stem Cell Disease Modeling and Precision Medicine - Innovative Genomics Institute

The Innovative Genomics Institute at the University of California, Berkeley seeks applications for a Postdoctoral Scholar Employee in the Advanced Translational Genetics (ATG) Lab, in the area of stem cell disease modeling and precision medicine.

The ATG Lab investigates the genetic and molecular underpinnings of human disease through the integration of high-throughput pluripotent stem cell (PSC) models. By combining precise genome editing, automated cell engineering, and multiplexed CRISPR screening with single-cell multi-omics and AI modeling, we are building a state-of-the-art cell type-specific disease modeling that provide unique therapeutic discovery platforms. Our mission is to decode complex disease mechanisms and accelerate the development of precision medicine across a broad spectrum of conditions, including oncology, neurodevelopmental and neurodegenerative disorders, and metabolic diseases.

Responsibilities:

The successful candidate will play a pivotal role in advancing our research through three primary functional domains:

Advanced Genome Engineering & Characterization

* Lead projects under the guidance of the Principal Investigator that involve engineering, differentiation to disease relevant cell types and functional characterization of human induced pluripotent stem cells (iPSCs).

* Execute complex molecular biology workflows, including large-scale tissue culture, PCR, NGS sequencing, high-resolution imaging, and biochemical functional assays to validate disease models.

Scaled CRISPR Discovery

* Design and execute sophisticated CRISPR screening campaigns, from library design and molecular cloning to lentiviral production.

* Manage scaled cell culture operations to support high-throughput genetic perturbations and therapeutic discovery.

Multi-Omic Data Integration & AI Modeling

* Develop and implement computational pipelines to analyze multi-module phenotypic data.

* Utilize pathway analysis and artificial intelligence (AI) modeling to derive biological insights and identify novel therapeutic targets from complex datasets.

In addition to overseeing their own research projects, the Postdoctoral Employee is expected to provide mentoring within the ATG research team.

* Mentorship & Collaboration: Provide technical guidance and professional mentorship to graduate and undergraduate students, fostering a collaborative and inclusive lab environment.

* Scientific Communication: Lead the preparation of high-impact manuscripts for peer-reviewed journals and present research findings at national and international conferences.

* Grant Development: Support the lab's sustainability by contributing preliminary data and strategic writing to federal and private grant proposals (e.g., NIH, NSF).

PhD (or equivalent international degree) or enrolled in a PhD degree program (or equivalent international degree).

Ph.D. (or equivalent international degree) required by the appointment start date.

No more than three years of post-degree research experience by start date.

Excellent writing and communication skills.

Strong publication record in peer reviewed journals.

PhD in cell biology, biochemistry, genetics, genomics, or a related field.

Demonstrated expertise in cell biology, genetics, genomics, or stem cell biology.

Expertise with methods such as multi-omics, CRISPR screens, iPSC disease modeling, genome engineering, Artificial Intelligence model-based omics or imaging data analysis is desirable.

• 3 required (contact information only)

UC Berkeley is committed to diversity, equity, inclusion, and belonging in our public mission of research, teaching, and service, consistent with UC Regents Policy 4400 and University of California Academic Personnel policy (APM 210 1-d). These values are embedded in our Principles of Community, which reflect our passion for critical inquiry, debate, discovery and innovation, and our deep commitment to contributing to a better world. Every member of the UC Berkeley community has a role in sustaining a safe, caring and humane environment in which these values can thrive.

The University of California, Berkeley is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.

For more information, please refer to the University of California's Affirmative Action and Nondiscrimination in Employment Policy and the University of California's Anti-Discrimination Policy.

In searches when letters of reference are required all letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality prior to submitting their letter.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

Unless stated otherwise, unambiguously, in the position description, this position does not include sponsorship of a new consular H-1B visa petition that would require payment of the $100,000 supplemental fee.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.

• "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment or discrimination, as defined by the employer.
• UC Sexual Violence and Sexual Harassment Policy
• UC Anti-Discrimination Policy
• APM - 035: Affirmative Action and Nondiscrimination in Employment