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Lab Head, Principal Scientist, Discovery Oncology

Genentech
United States, California, South San Francisco
Oct 29, 2025
The Position

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.

The Opportunity

The Department of Discovery Oncology at Genentech is thrilled to announce a unique opportunity for a highly skilled, highly motivated Principal Scientist to lead a lab-based research group. We seek an exceptional candidate with expertise in the biology of hormone-dependent cancers, specifically of the breast and prostate, who will be dedicated to discovering and developing new therapies.

The successful candidate will work closely with our Drug Development, Translational Medicine, Computational and Clinical Science colleagues to formulate new therapeutic hypotheses and to advance transformative medicines. This is a particularly exciting time to join the team, as we build considerable momentum with a rich portfolio of breast and prostate cancer programs.

Key responsibilities include:

  • Research Leadership: Lead and manage a high-performing team that discovers novel targets and/or progresses cutting-edge therapies in hormone-dependent cancers.

  • Interdisciplinary Collaboration: Work closely with internal experts across departments and disciplines to drive innovative therapeutic strategies.

  • Innovative Drug Discovery: Leverage advanced tools and approaches to identify new targets and/or advance the targeting of biological axes known to be critical for tumors.

  • Translational Impact: Generate high-quality, original research that advances our understanding of hormone-dependent cancer biology and therapeutics.

  • Communication and Collaboration: Foster a collaborative environment and ensure that data-driven insights are effectively translated into actionable drug discovery and clinical strategies.

Who You Are

  • Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field.

  • Experience: Minimum 4 years post-Ph.D. of productive postdoctoral training and/or industry experience. Your record should reflect high-impact publications, patents, and/or successful project transitions.

  • Technical Expertise: Demonstrated expertise in breast or prostate cancer research, encompassing biochemical, molecular and/or cell biology approaches.

  • Leadership and Collaboration: Exceptional leadership potential and a track record of working with multidisciplinary teams, excellent written and verbal communication skills, and a collaborative spirit.

Preferreds

  • Familiarity with leading-edge drug discovery approaches (e.g. molecular glues, induced proximity) would be advantageous.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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