Sr. Scientist, Neuroimmunology

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciencesis a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visitneurocrine.com, and follow the company onLinkedIn,XandFacebook. (*in collaboration with AbbVie)

About the Role:

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• Designs and performs multiple experiments to support scientific activities and project goals involving cell including primary human leukocytes, mouse splenocytes and biochemical assays

• Generates and interprets data and works with complex assay system, with a strong understanding of advanced data analysis and statistical tests

• Manges advanced cell-based assay development, including primary cells, coculture and ex vivo tissues

• Independently sets up the in vitro assays to understand the cellular functions of innate and adaptive immune cells as well as the cell-cell interaction

• Advanced experience in isolating primary immune cells from various organs in experimental animal models.

• Expert experience in human PBMC isolation, lymphocyte proliferation, activation, cytokine secretion and differentiation assays

• Conduct multiple color flow cytometry assay including intracellular staining and prepare for cell sorting as well as flowcytometry data analysis

• Creates and maintains SOP's and writes data summaries for experiments conducted

• Provides training and/or supervision to junior staff, as needed

• Other duties as assigned

• BS/BA degree and 4+ years of relevant experience OR

• MS degree and 2+ years OR

• PhD and some relevant experience; may include postdoc experience

• Advanced tissue culture techniques, including knowledge of human PBMC isolation, mouse splenocyte, iPCS and precursor cell handling and differentiation as well as hematopoietic cell differentiation

• Strong knowledge of NGS technologies, their implementation, and data analysis & relevant statistical tests

• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)

• Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH

• Advanced knowledge of one or more scientific disciplines especially Immunology

• Advanced knowledge of scientific principles, methods and techniques.

• Advanced knowledge and demonstrated ability working with a variety of laboratory equipment/tools.

• Basic molecular biology skills including mRNA isolation, TagMan, NanoString and scRNAseq experience is highly desirable

• In vivo experience of autoimmune diseases and other inflammatory diseases is a plus

• Ability to work as part of a team; may train lower levels.

• Excellent computer skills

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Strong project management skills

• Demonstrates solid level of understanding project / group goals and methods

• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes

• Able to explain the process behind the data and implications of the results

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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